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Conclusion: These data support the hypothesis that reduced renal Gstm1 plays a role in the development of hypertension

Patients should be provided with clear safety advice , including when to temporarily discontinue SGLT2 inhibitors (during acute illness, dehydration, or 3 days before surgery), recognition of DKA symptoms (nausea, vomiting, abdominal pain, unusual fatigue), and management of genitourinary infections

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